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6 October 2026 · National and international edition

DNA Written Without a Template: Bacterial Enzyme DRT3b Tests, but Does Not Overturn, Biology's Central Dogma

  • Science & Technology
  • GS-III
  • The Hindureported it
  • Central Dogma
  • Reverse Transcriptase
  • Molecular Biology
  • Bacteriophage
  • Biotechnology

Why it is in the news

Two recent papers, in Science and Cell, have described a bacterial anti-virus system, DRT3, in which one enzyme — DRT3b — writes a defined DNA sequence (a CACACA… repeat) without any nucleic-acid template, the protein itself dictating the order of nucleotides. Accompanying commentaries asked whether this breaches Francis Crick's central dogma of molecular biology; the consensus reading is that it stretches but does not overturn it.

The exam angle

Thesis: Scientific 'laws' in biology are generalisations that hold until nature offers an exception; the DRT3b finding refines rather than refutes the central dogma, showing how precise definitions protect a theory's explanatory power.

Written for APPSC Group 1, TGPSC Group 1 and UPSC Civil Services. More from 6 October 2026 or all current affairs.

DNA Written Without a Template: Bacterial Enzyme DRT3b Tests, but Does Not Overturn, Biology's Central Dogma · PrepShark